PNPLA1

Across TCGA pan-cancer cohorts, PNPLA1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PNPLA1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where PNPLA1 RNA is repressed in tumor relative to normal tissue. In most cancer types PNPLA1 is over-expressed in tumor, although a few such as KIRP and THCA show the opposite, repressed pattern.

KIRP, THCA, and KICH are the cancer types where PNPLA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PNPLA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	IV	−2.724	<.001	11	view →
THCA	Male	III,IV	−0.311	<.001	9	view →
KICH	Female	All	−1.762	<.001	7	view →
HNSC	All	All	+0.610	.009	7	view →
KIRC	All	All	−0.836	<.001	5	view →
BLCA	Male	IV	+0.600	.033	5	view →
COAD	All	All	+0.270	.023	5	view →
LUSC	Male	All	+0.649	<.001	4	view →
BRCA	All	II,III,IV	+0.162	.001	4	view →
STAD	Male	IV	−0.950	.002	3	view →
ESCA	Female	All	−2.453	.021	2	view →
PRAD	All	All	−0.103	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PNPLA1–KIRP

Open the KIRP breakdown →