PNPLA1

Across TCGA patient cohorts, PNPLA1 mutation is significantly associated with the RNA expression of many other genes, with 1,105 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNPLA1-associated genes across cancer lineages are MIR873, RNU6-694P, and LRRC43. Each is linked with PNPLA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PNPLA1-to-partner and partner-to-PNPLA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR873 grouped by PNPLA1-low versus PNPLA1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA1→partner) and Y-score (partner→PNPLA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR873 →	+0.333	+7.954	<.001	.008	3	3
LUSC	RNU6-694P →	+0.170	+4.578	.001	.005	3	3
SKCM	LRRC43 →	-0.418	-3.649	.007	.001	3	2
LIHC	RNA5SP256 →	+0.279	+4.544	<.001	.009	3	2
KIRP	HTN1 →	+0.015	+5.060	<.001	.008	3	2
KIRP	FTMT →	+0.073	+4.967	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,105 associations by consensus.

MIR873 by PNPLA1 expression — HNSC

Explore this box plot interactively →