PNPLA1

Across TCGA patient cohorts, PNPLA1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNPLA1-associated genes across cancer lineages are p38-MAPK_pT180_Y182, PDCD4, and YAP. Each is linked with PNPLA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PNPLA1-to-partner and partner-to-PNPLA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by PNPLA1-low versus PNPLA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA1→partner) and Y-score (partner→PNPLA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.445	-1.401	.008	.046	3	2
UCEC	PDCD4 →	-0.414	-1.415	.019	.046	3	2
UCEC	YAP →	+0.113	+1.884	.044	.030	3	2
UCEC	ATM →	-0.349	-1.765	.040	.014	3	2
UCEC	Caspase-8 →	-0.228	-3.780	.015	<.001	3	2
UCEC	EGFR_pY1068 →	-0.204	-1.765	.030	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

p38-MAPK_pT180_Y182 by PNPLA1 expression — UCEC

Explore this box plot interactively →