PNPLA1

Across TCGA cell cohorts, PNPLA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,052 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PNPLA1-associated GO terms across cancer lineages are Protein targeting to ER, Regulation of response to cytokine stimulus, and Post-translational protein targeting to endoplasmic reticulum membrane. Each is linked with PNPLA1 in more than 6 cancer types. Because this analysis shows association rather than direction, both PNPLA1-to-partner and partner-to-PNPLA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein targeting to ER grouped by PNPLA1-low versus PNPLA1-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA1→partner) and Y-score (partner→PNPLA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Protein targeting to ER →	+0.052	+0.574	<.001	.004	3	7
LUNG_SCLC	Regulation of response to cytokine stimulus →	+0.041	+0.358	<.001	.002	3	7
OVARY	Post-translational protein targeting to endoplasmic reticulum membrane →	+0.058	+0.071	<.001	.007	3	6
BLOOD_Leukemia	Response to endoplasmic reticulum stress →	+0.027	+0.578	.006	.005	3	6
SKIN	Membrane protein ectodomain proteolysis →	+0.088	+0.035	.003	.002	3	6
SOFT_TISSUE	Positive regulation of innate immune response →	+0.050	+0.059	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,052 associations by consensus.

Protein targeting to ER by PNPLA1 expression — BLOOD_Leukemia

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