PNPLA1

Across TCGA cell cohorts, PNPLA1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PNPLA1-associated genes across cancer lineages are UTF1, LGALS16, and CST8. Each is linked with PNPLA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PNPLA1-to-partner and partner-to-PNPLA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UTF1 grouped by PNPLA1-low versus PNPLA1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA1→partner) and Y-score (partner→PNPLA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	UTF1 →	+0.046	+4.906	<.001	.006	3	1
OESOPHAGUS	LGALS16 →	+0.046	+4.906	<.001	.006	3	1
LARGE_INTESTINE	CST8 →	+0.029	+5.415	<.001	.004	3	1
SKIN	OR2A5 →	+0.064	+4.977	.007	.007	3	1
SKIN	CFHR2 →	+0.060	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

UTF1 by PNPLA1 expression — OESOPHAGUS

Explore this box plot interactively →