PNOC

Across TCGA patient cohorts, PNOC mutation is significantly associated with the RNA expression of many other genes, with 1,165 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNOC-associated genes across cancer lineages are SNORD116-11, RNU4-58P, and SALRNA3. Each is linked with PNOC in more than 1 cancer types. Because this analysis shows association rather than direction, both PNOC-to-partner and partner-to-PNOC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD116-11 grouped by PNOC-low versus PNOC-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNOC→partner) and Y-score (partner→PNOC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SNORD116-11 →	+0.250	+5.219	<.001	.002	3	2
UCEC	RNU4-58P →	+0.253	+2.963	<.001	.003	3	2
SKCM	SALRNA3 →	+0.051	+3.380	.002	.007	3	2
BLCA	MTCO3P39 →	+0.120	+5.018	<.001	.004	3	2
BLCA	PRELID3BP8 →	+0.282	+4.588	<.001	.008	3	2
UCEC	ESS2 →	+0.363	+3.595	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,165 associations by consensus.

SNORD116-11 by PNOC expression — SKCM

Explore this box plot interactively →