PNN

Across TCGA patient cohorts, PNN protein abundance is significantly associated with the RNA expression of many other genes, with 20,062 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PNN-associated genes across cancer lineages are TMEM97, TGIF2, and MYBL2. Each is linked with PNN in more than 7 cancer types. Because this analysis shows association rather than direction, both PNN-to-partner and partner-to-PNN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PNN versus TMEM97 in HNSC, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNN→partner) and Y-score (partner→PNN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TMEM97 →	+1.119	+0.202	<.001	<.001	3	8
HNSC	TGIF2 →	+0.723	+0.163	.001	.001	3	8
BRCA	MYBL2 →	+1.549	+0.243	<.001	.001	3	7
UCEC	TIMELESS →	+0.970	+0.200	<.001	<.001	3	7
OV	DSE →	-0.734	-0.264	<.001	<.001	3	7
LSCC	HELLS →	+0.911	+0.216	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,062 associations by consensus.

PNN vs TMEM97 — HNSC

Explore this scatter interactively →