PNN

Across TCGA pan-cancer cohorts, PNN RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated PNN data layer compared with 6 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PNN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PNN expression acts as an unfavorable survival marker, although some lineages such as BRCA and UCS show a favorable association.

ACC, LIHC, and KICH are the cancer types where PNN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.310	0.839	<.001	99	view →
LIHC	OS	Median	All	0.439	0.577	.002	55	view →
KICH	DFS	Quartile	III,IV	0.179	1.000	.003	49	view →
BRCA	OS	Median	III,IV	0.669	0.414	<.001	38	view →
UCS	DFS	Median	IV	0.952	0.367	.001	36	view →
COAD	DFS	Tertile	All	0.679	0.831	.002	31	view →
GBM	DFS	Quartile	All	0.577	0.216	<.001	29	view →
KIRC	DFS	Tertile	II,III,IV	0.296	0.610	.004	21	view →
PRAD	OS	Median	All	0.975	1.000	.007	20	view →
SKCM	DFS	Quartile	All	0.794	0.622	.009	15	view →
KIRP	DFS	Tertile	All	0.629	0.798	.017	14	view →
THYM	DFS	Median	All	0.865	0.617	.008	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

PNN–ACC (DFS)

Open the ACC breakdown →