PNN

Across TCGA patient cohorts, PNN mutation is significantly associated with the RNA expression of many other genes, with 5,394 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNN-associated genes across cancer lineages are RNA5SP369, RAD51AP1, and RIC8B. Each is linked with PNN in more than 2 cancer types. Because this analysis shows association rather than direction, both PNN-to-partner and partner-to-PNN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP369 grouped by PNN-low versus PNN-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNN→partner) and Y-score (partner→PNN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP369 →	+0.137	+4.408	<.001	.005	3	3
UCEC	RAD51AP1 →	+0.630	+2.457	.001	.001	3	2
UCEC	RIC8B →	+0.306	+2.928	.001	<.001	3	2
UCEC	GMNN →	+0.698	+2.390	<.001	<.001	3	2
UCEC	RLF →	+0.466	+1.658	<.001	.001	3	2
UCEC	NEK2 →	+0.614	+3.818	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,394 associations by consensus.

RNA5SP369 by PNN expression — SKCM

Explore this box plot interactively →