PNN

Across TCGA patient cohorts, PNN mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNN-associated genes across cancer lineages are Annexin_VII, A-Raf_pS299, and FoxM1. Each is linked with PNN in more than 2 cancer types. Because this analysis shows association rather than direction, both PNN-to-partner and partner-to-PNN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin_VII grouped by PNN-low versus PNN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNN→partner) and Y-score (partner→PNN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin_VII →	-0.117	-2.115	.007	<.001	3	3
UCEC	A-Raf_pS299 →	-0.083	-2.087	.027	.005	3	2
UCEC	FoxM1 →	+0.198	+1.836	.015	.001	3	2
UCEC	GAPDH →	+0.389	+1.247	.021	.041	3	2
UCEC	Notch1 →	+0.114	+1.424	.010	.027	3	2
UCEC	Rad50 →	-0.218	-1.584	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Annexin_VII by PNN expression — UCEC

Explore this box plot interactively →