PNN

Across TCGA cell cohorts, PNN RNA expression is significantly associated with the go_rna of many other GO terms, with 4,705 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PNN-associated GO terms across cancer lineages are DNA-templated DNA replication maintenance of fidelity, Double-strand break repair, and DNA recombination. Each is linked with PNN in more than 19 cancer types. Because this analysis shows association rather than direction, both PNN-to-partner and partner-to-PNN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated DNA replication maintenance of fidelity grouped by PNN-low versus PNN-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PNN→partner) and Y-score (partner→PNN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA-templated DNA replication maintenance of fidelity →	+0.149	+1.291	.001	.001	3	20
BREAST	Double-strand break repair →	+0.067	+0.836	<.001	<.001	3	19
BONE	DNA recombination →	+0.078	+1.120	.005	<.001	3	19
BONE	Positive regulation of DNA metabolic process →	+0.066	+0.960	.006	.002	3	19
UPPER_AERODIGESTIVE_TRACT	DNA replication →	+0.118	+1.327	<.001	<.001	3	18
OESOPHAGUS	Regulation of DNA repair →	+0.068	+1.275	<.001	.007	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,705 associations by consensus.

DNA-templated DNA replication maintenance of fidelity by PNN expression — BONE

Explore this box plot interactively →