PNN

Across TCGA cell cohorts, PNN mutation is significantly associated with the RNA expression of many other genes, with 393 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PNN-associated genes across cancer lineages are JOSD1, TIMM9, and CCDC113. Each is linked with PNN in more than 1 cancer types. Because this analysis shows association rather than direction, both PNN-to-partner and partner-to-PNN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JOSD1 grouped by PNN-low versus PNN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNN→partner) and Y-score (partner→PNN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	JOSD1 →	+0.562	+3.212	.005	.006	3	1
LARGE_INTESTINE	TIMM9 →	+0.541	+3.212	.002	.006	3	1
LARGE_INTESTINE	CCDC113 →	+0.922	+3.299	.001	.004	3	1
LARGE_INTESTINE	CLUAP1 →	+0.702	+3.385	.001	.004	3	1
LARGE_INTESTINE	SH3GL2 →	+1.395	+3.837	<.001	<.001	3	1
LARGE_INTESTINE	HIPK3 →	+0.601	+3.212	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 393 associations by consensus.

JOSD1 by PNN expression — LARGE_INTESTINE

Explore this box plot interactively →