PNMT

Across TCGA patient cohorts, PNMT RNA expression is significantly associated with the protein abundance of many other proteins, with 11,879 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PNMT-associated proteins across cancer lineages are TMF1, PPP1R18, and COPB1. Each is linked with PNMT in more than 3 cancer types. Because this analysis shows association rather than direction, both PNMT-to-partner and partner-to-PNMT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PNMT versus TMF1 in UCEC, with a Pearson correlation of -0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMT→partner) and Y-score (partner→PNMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMF1 →	-0.253	-1.052	.001	.002	3	4
GBM	PPP1R18 →	-0.299	-0.704	<.001	<.001	3	4
OV	COPB1 →	-0.218	-1.160	.001	.002	3	4
GBM	CNRIP1 →	+0.515	+0.623	<.001	<.001	3	4
OV	LARP4 →	-1.660	-1.712	.001	.001	3	3
OV	MTFR1L →	+0.334	+1.007	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,879 associations by consensus.

PNMT vs TMF1 — UCEC

Explore this scatter interactively →