PNMT

Across TCGA patient cohorts, PNMT mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNMT-associated genes across cancer lineages are pDC and MEP. Each is linked with PNMT in more than 1 cancer types. Because this analysis shows association rather than direction, both PNMT-to-partner and partner-to-PNMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, pDC grouped by PNMT-low versus PNMT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMT→partner) and Y-score (partner→PNMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	pDC →	+0.054	+2.839	.032	.034	3	2
UCEC	MEP →	+0.050	+2.839	<.001	.035	2	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

pDC by PNMT expression — UCEC

Explore this box plot interactively →