PNMT

Across TCGA cell cohorts, PNMT RNA expression is significantly associated with the go_rna of many other GO terms, with 2,420 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PNMT-associated GO terms across cancer lineages are Regulation of myoblast fusion, Translational initiation, and mRNA 3'-end processing. Each is linked with PNMT in more than 8 cancer types. Because this analysis shows association rather than direction, both PNMT-to-partner and partner-to-PNMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myoblast fusion grouped by PNMT-low versus PNMT-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMT→partner) and Y-score (partner→PNMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of myoblast fusion →	+0.119	+1.617	<.001	.002	3	9
STOMACH	Translational initiation →	+0.084	+2.299	<.001	<.001	3	9
BLOOD_Leukemia	mRNA 3'-end processing →	+0.042	+1.422	.001	.003	3	9
OVARY	Negative regulation of mRNA metabolic process →	+0.086	+0.566	<.001	<.001	2	9
STOMACH	Cytoplasmic translation →	+0.080	+1.336	<.001	.001	3	8
STOMACH	Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway →	+0.080	+1.457	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,420 associations by consensus.

Regulation of myoblast fusion by PNMT expression — STOMACH

Explore this box plot interactively →