PNMA8A

Across TCGA patient cohorts, PNMA8A mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNMA8A-associated genes across cancer lineages are MIG-6, Stathmin, and MSH6. Each is linked with PNMA8A in more than 1 cancer types. Because this analysis shows association rather than direction, both PNMA8A-to-partner and partner-to-PNMA8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by PNMA8A-low versus PNMA8A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMA8A→partner) and Y-score (partner→PNMA8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIG-6 →	+0.134	+3.229	.005	.009	3	2
COAD	Stathmin →	+0.185	+2.820	.014	.035	3	2
COAD	MSH6 →	-0.667	-3.000	<.001	.034	3	1
UCEC	EGFR_pY1068 →	-0.283	-2.807	.009	.003	3	1
UCEC	EGFR_pY1173 →	+0.072	+1.611	.040	.043	3	1
UCEC	A-Raf_pS299 →	-0.129	-3.321	.013	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

MIG-6 by PNMA8A expression — COAD

Explore this box plot interactively →