PNMA8A

Across TCGA cell cohorts, PNMA8A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,284 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PNMA8A-associated GO terms across cancer lineages are Transcription initiation at RNA polymerase II promoter, Protein-DNA complex organization, and DNA-templated transcription initiation. Each is linked with PNMA8A in more than 10 cancer types. Because this analysis shows association rather than direction, both PNMA8A-to-partner and partner-to-PNMA8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription initiation at RNA polymerase II promoter grouped by PNMA8A-low versus PNMA8A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMA8A→partner) and Y-score (partner→PNMA8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Transcription initiation at RNA polymerase II promoter →	+0.070	+2.543	.001	<.001	3	11
BONE	Protein-DNA complex organization →	+0.077	+2.266	<.001	<.001	3	9
OESOPHAGUS	DNA-templated transcription initiation →	+0.079	+0.053	.003	.007	2	10
BONE	Protein-DNA complex assembly →	+0.066	+2.266	<.001	<.001	3	9
SOFT_TISSUE	Protein localization to nucleus →	+0.048	+1.978	.002	.001	3	9
BONE	Positive regulation of DNA metabolic process →	+0.072	+1.766	<.001	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,284 associations by consensus.

Transcription initiation at RNA polymerase II promoter by PNMA8A expression — BONE

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