PNMA8A

Across TCGA cell cohorts, PNMA8A mutation is significantly associated with the mutation status of many other genes, with 1,536 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PNMA8A-associated genes across cancer lineages are ABI2, NR4A2, and ASB4. Each is linked with PNMA8A in more than 2 cancer types. Because this analysis shows association rather than direction, both PNMA8A-to-partner and partner-to-PNMA8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ABI2 grouped by PNMA8A-low versus PNMA8A-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMA8A→partner) and Y-score (partner→PNMA8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ABI2 →	+4.239	+5.053	.007	.007	1	3
SKIN	NR4A2 →	+4.239	+5.053	.007	.007	1	3
LARGE_INTESTINE	ASB4 →	+3.007	+3.584	.008	.008	1	3
LARGE_INTESTINE	SAMD9 →	+2.422	+4.050	.004	.004	1	3
SKIN	AKR1B15 →	+4.824	+5.392	.004	.004	1	3
LARGE_INTESTINE	DMP1 →	+4.329	+4.329	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,536 associations by consensus.

ABI2 by PNMA8A expression — SKIN

Explore this box plot interactively →