Across TCGA patient cohorts, PNMA3 mutation is significantly associated with the RNA expression of many other genes, with 1,512 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNMA3-associated genes across cancer lineages are CLDN7P1, RPS29P32, and RNA5SP369. Each is linked with PNMA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PNMA3-to-partner and partner-to-PNMA3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMA3→partner) and Y-score (partner→PNMA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	CLDN7P1 →	+0.120	+3.371	<.001	.002	3	2
UCEC	RPS29P32 →	+0.306	+1.844	<.001	.002	3	2
BRCA	RNA5SP369 →	+0.394	+6.866	<.001	<.001	3	2
LUSC	RPL12P34 →	+0.252	+3.414	<.001	.006	3	2
LUAD	DUX4L31 →	+0.047	+4.399	<.001	.008	3	2
LUAD	VN1R69P →	+0.091	+4.730	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,512 associations by consensus.

Exploration

PNMA3 survival (RNA) · tumor vs normal (RNA) · all PNMA3 data types