Q-omics provides the consensus-scored DUX4L31 profile across patient tissues and cancer cell-line models. DUX4L31 expression is associated with patient survival in 7 of 34 cancer types, with the highest sampling consensus in KIRP. Additionally, DUX4L31 RNA expression shows 4,676 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight KIRP, and STAD as cancer lineages where DUX4L31 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes DUX4L31 survival associations across molecular data types. DUX4L31 RNA expression shows survival associations in the most cancer types (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

DUX4L31 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	7	KIRP (108)	view →

This table ranks reproducible DUX4L31 RNA expression–survival associations across cancer types. High DUX4L31 expression shows unfavorable associations in KIRP, TGCT, LGG and STAD, but favorable associations in GBM and HNSC. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for DUX4L31 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.608	0.916	<.001	108	view →
TGCT	DFS	Tertile	II,III,IV	0.015	0.919	<.001	36	view →
LGG	DFS	Tertile	All	0.460	0.835	<.001	33	view →
STAD	OS	Tertile	All	0.460	0.734	.006	18	view →
GBM	DFS	Tertile	All	1.000	0.204	.042	9	view →
HNSC	DFS	Tertile	All	0.921	0.614	.027	9	view →

Pink = unfavorable, green = favorable. all 7 lineages →

DUX4L31-KIRP (DFS)

Kaplan–Meier survival curve for DUX4L31 RNA expression in KIRP: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with DUX4L31 in patient tissues and cancer cell lines. In patient samples, DUX4L31 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
Function (RNA)	4,676	STAD (4250)	view →
RNA	3,310	ESCA (1052)	view →