PNLIPRP2

Across TCGA patient cohorts, PNLIPRP2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNLIPRP2-associated genes across cancer lineages are p38-MAPK, VEGFR2, and 4E-BP1. Each is linked with PNLIPRP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PNLIPRP2-to-partner and partner-to-PNLIPRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK grouped by PNLIPRP2-low versus PNLIPRP2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNLIPRP2→partner) and Y-score (partner→PNLIPRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	p38-MAPK →	-0.225	-2.917	.010	.034	3	2
UCEC	VEGFR2 →	+0.314	+1.920	.008	.009	3	2
UCEC	4E-BP1 →	+0.320	+3.199	.003	.009	2	3
UCEC	Cyclin-B1 →	+0.628	+1.906	.005	.016	3	2
LUAD	Cyclin-E2 →	+0.261	+3.016	<.001	.019	3	1
UCEC	14-3-3_beta →	-0.096	-1.847	.017	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

p38-MAPK by PNLIPRP2 expression — LUAD

Explore this box plot interactively →