PNKP

Across TCGA cell cohorts, PNKP mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PNKP-associated genes across cancer lineages are KCNK17, OR10W1, and C10orf53. Each is linked with PNKP in more than 1 cancer types. Because this analysis shows association rather than direction, both PNKP-to-partner and partner-to-PNKP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNK17 grouped by PNKP-low versus PNKP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNKP→partner) and Y-score (partner→PNKP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KCNK17 →	+0.072	+3.906	<.001	.002	3	1
LARGE_INTESTINE	OR10W1 →	+0.016	+3.977	<.001	.001	3	1
LARGE_INTESTINE	C10orf53 →	+0.012	+3.632	<.001	.003	3	1
LARGE_INTESTINE	C14orf180 →	+0.165	+4.155	<.001	.003	3	1
LARGE_INTESTINE	TEX35 →	+0.097	+3.554	.008	.007	3	1
BLOOD_Leukemia	ADRA1A →	+0.375	+4.705	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

KCNK17 by PNKP expression — LARGE_INTESTINE

Explore this box plot interactively →