PNISR

Across TCGA cell cohorts, PNISR mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PNISR-associated genes across cancer lineages are NCMAP, CHRNA2, and SPACA5. Each is linked with PNISR in more than 1 cancer types. Because this analysis shows association rather than direction, both PNISR-to-partner and partner-to-PNISR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCMAP grouped by PNISR-low versus PNISR-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNISR→partner) and Y-score (partner→PNISR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NCMAP →	+0.303	+4.554	<.001	<.001	3	2
SOFT_TISSUE	CHRNA2 →	+0.106	+3.999	.009	.004	3	1
SOFT_TISSUE	SPACA5 →	+0.965	+4.142	.002	.003	3	1
SOFT_TISSUE	FADS6 →	+0.185	+3.684	<.001	.009	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+5.507	<.001	<.001	3	1
BLOOD_Leukemia	ADRA1A →	+0.375	+4.705	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

NCMAP by PNISR expression — SOFT_TISSUE

Explore this box plot interactively →