Across TCGA patient cohorts, PMS2CL mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PMS2CL-associated genes across cancer lineages are Notch1, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with PMS2CL in more than 1 cancer types. Because this analysis shows association rather than direction, both PMS2CL-to-partner and partner-to-PMS2CL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMS2CL→partner) and Y-score (partner→PMS2CL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.171	+2.321	.003	.006	3	2
UCEC	Caspase-7-cleavedD198 →	+0.824	+1.807	<.001	.027	3	2
UCEC	EGFR_pY1068 →	-0.223	-3.459	.031	.005	3	1
UCEC	ERK2 →	+0.207	+3.321	.009	.009	3	1
UCEC	JNK_pT183_Y185 →	-0.176	-2.459	.011	.019	3	1
UCEC	MEK1 →	+0.316	+1.807	.036	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

PMS2CL survival (RNA) · tumor vs normal (RNA) · all PMS2CL data types