PMS2

Across TCGA cell cohorts, PMS2 mutation is significantly associated with the RNA expression of many other genes, with 334 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PMS2-associated genes across cancer lineages are C14orf180, ACER1, and MIS12. Each is linked with PMS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PMS2-to-partner and partner-to-PMS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C14orf180 grouped by PMS2-low versus PMS2-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMS2→partner) and Y-score (partner→PMS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	C14orf180 →	+0.389	+5.087	<.001	.004	3	2
BLOOD_Leukemia	ACER1 →	+0.185	+3.318	.004	.005	3	2
BLOOD_Leukemia	MIS12 →	+0.638	+3.199	.006	.007	3	2
UPPER_AERODIGESTIVE_TRACT	C4orf50 →	+0.013	+4.736	<.001	.009	3	2
URINARY_TRACT	CLLU1-AS1 →	+0.113	+5.087	<.001	.004	3	1
URINARY_TRACT	CT45A6 →	+0.036	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 334 associations by consensus.

C14orf180 by PMS2 expression — URINARY_TRACT

Explore this box plot interactively →