PMM1

Across TCGA cell cohorts, PMM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,642 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PMM1-associated GO terms across cancer lineages are GDP-mannose biosynthetic process, Actin filament depolymerization, and Response to aldosterone. Each is linked with PMM1 in more than 13 cancer types. Because this analysis shows association rather than direction, both PMM1-to-partner and partner-to-PMM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GDP-mannose biosynthetic process grouped by PMM1-low versus PMM1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PMM1→partner) and Y-score (partner→PMM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GDP-mannose biosynthetic process →	+0.177	+1.226	.002	<.001	2	14
UPPER_AERODIGESTIVE_TRACT	Actin filament depolymerization →	+0.177	+0.971	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Response to aldosterone →	-0.235	-0.999	.003	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Caveolin-mediated endocytosis →	+0.204	+0.776	<.001	.002	3	10
LUNG_NSCLC_LUAD	Protein localization to microtubule plus-end →	+0.155	+0.716	<.001	<.001	3	10
LUNG_NSCLC_LUAD	Protein localization to microtubule end →	+0.155	+0.716	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,642 associations by consensus.

GDP-mannose biosynthetic process by PMM1 expression — URINARY_TRACT

Explore this box plot interactively →