PMM1

Across TCGA pan-cancer cohorts, PMM1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PMM1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PMM1 RNA is repressed in tumor relative to normal tissue. In most cancer types PMM1 is over-expressed in tumor, although a few such as LUAD and KIRP show the opposite, repressed pattern.

LUAD, KIRP, and COAD are the cancer types where PMM1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PMM1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	−1.142	<.001	9	view →
KIRP	Male	All	−0.772	<.001	8	view →
COAD	All	II,III,IV	−0.374	.004	8	view →
KICH	Female	All	−1.593	<.001	7	view →
READ	All	All	−0.666	.009	6	view →
STAD	All	All	−0.584	.003	6	view →
LUSC	Male	II,III,IV	−0.725	<.001	5	view →
UCEC	All	II,III,IV	−0.899	.005	4	view →
LIHC	All	All	+0.477	.001	4	view →
BRCA	All	All	−0.297	<.001	4	view →
KIRC	Female	All	+0.431	.019	3	view →
CHOL	All	All	+1.091	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PMM1–LUAD

Open the LUAD breakdown →