PML

Across TCGA patient cohorts, PML protein abundance is significantly associated with the RNA expression of many other genes, with 14,915 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PML-associated genes across cancer lineages are RUFY4, IL16, and ETV7. Each is linked with PML in more than 8 cancer types. Because this analysis shows association rather than direction, both PML-to-partner and partner-to-PML results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PML versus RUFY4 in OV, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PML→partner) and Y-score (partner→PML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RUFY4 →	+1.039	+0.405	<.001	.001	3	9
BRCA	IL16 →	+0.716	+0.429	<.001	<.001	3	9
OV	ETV7 →	+1.190	+0.482	<.001	<.001	3	8
UCEC	CD40 →	+1.023	+0.285	<.001	<.001	3	8
HNSC	IFIT3 →	+2.441	+0.643	<.001	<.001	3	8
BRCA	IFI44L →	+1.421	+0.403	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,915 associations by consensus.

PML vs RUFY4 — OV

Explore this scatter interactively →