PML

Across TCGA pan-cancer cohorts, PML RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PML’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PML RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PML is over-expressed in tumor, although a few such as BRCA and UCEC show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where PML tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PML RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.382	<.001	12	view →
KIRC	Male	IV	+1.295	<.001	12	view →
COAD	Female	II,III,IV	+0.976	<.001	12	view →
KIRP	Male	III,IV	+1.197	<.001	9	view →
LIHC	Female	II,III,IV	+1.190	<.001	9	view →
THCA	Male	All	+0.426	<.001	9	view →
STAD	Male	II,III,IV	+1.163	<.001	6	view →
CHOL	All	All	+2.227	<.001	5	view →
READ	All	All	+0.807	<.001	5	view →
BRCA	Female	II,III,IV	−0.222	.002	4	view →
ESCA	All	All	+1.387	.002	2	view →
UCEC	All	All	−0.497	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PML–HNSC

Open the HNSC breakdown →