PML

Across TCGA patient cohorts, PML mutation is significantly associated with the RNA expression of many other genes, with 6,981 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PML-associated genes across cancer lineages are USP1, UPF2, and LZIC. Each is linked with PML in more than 4 cancer types. Because this analysis shows association rather than direction, both PML-to-partner and partner-to-PML results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP1 grouped by PML-low versus PML-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PML→partner) and Y-score (partner→PML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	USP1 →	+0.611	+2.021	<.001	<.001	3	5
UCEC	UPF2 →	+0.393	+1.784	.001	<.001	3	4
UCEC	LZIC →	+0.589	+2.513	<.001	<.001	3	4
UCEC	ABHD18 →	+0.431	+2.247	<.001	<.001	3	4
UCEC	SFXN1 →	+0.617	+2.237	<.001	<.001	3	4
UCEC	ZNF367 →	+0.875	+2.237	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,981 associations by consensus.

USP1 by PML expression — UCEC

Explore this box plot interactively →