PML

Across TCGA patient cohorts, PML mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PML-associated genes across cancer lineages are PCNA, Cyclin-B1, and eIF4E. Each is linked with PML in more than 3 cancer types. Because this analysis shows association rather than direction, both PML-to-partner and partner-to-PML results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PML-low versus PML-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PML→partner) and Y-score (partner→PML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.175	+1.473	.008	.006	3	4
UCEC	Cyclin-B1 →	+0.504	+1.473	.003	.006	3	4
UCEC	eIF4E →	+0.177	+2.235	.006	.005	3	3
UCEC	mTOR_pS2448 →	-0.119	-1.893	.009	.014	3	3
UCEC	p27_pT198 →	+0.066	+1.473	.043	.006	3	3
UCEC	STAT3_pY705 →	-0.330	-3.169	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

PCNA by PML expression — UCEC

Explore this box plot interactively →