PML

Across TCGA cell cohorts, PML RNA expression is significantly associated with the go_rna of many other GO terms, with 5,838 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PML-associated GO terms across cancer lineages are Positive regulation of protein localization to chromosome, telomeric region, Regulation of protein localization to chromosome, telomeric region, and Regulation of apoptotic process involved in development. Each is linked with PML in more than 18 cancer types. Because this analysis shows association rather than direction, both PML-to-partner and partner-to-PML results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein localization to chromosome, telomeric region grouped by PML-low versus PML-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PML→partner) and Y-score (partner→PML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of protein localization to chromosome, telomeric region →	+0.142	+1.110	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Regulation of protein localization to chromosome, telomeric region →	+0.154	+1.516	<.001	<.001	3	19
LUNG_SCLC	Regulation of apoptotic process involved in development →	+0.815	+0.759	.004	<.001	3	18
URINARY_TRACT	Negative regulation of translational initiation in response to stress →	+0.153	+0.972	<.001	.002	3	18
BONE	Fibroblast migration →	+0.303	+1.397	<.001	<.001	3	17
LUNG_SCLC	Positive regulation of apoptotic process involved in morphogenesis →	+1.056	+0.996	.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,838 associations by consensus.

Positive regulation of protein localization to chromosome, telomeric region by PML expression — SOFT_TISSUE

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