PML

Across TCGA cell cohorts, PML mutation is significantly associated with the RNA expression of many other genes, with 1,184 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PML-associated genes across cancer lineages are FZD3, ARMC1, and ARL6. Each is linked with PML in more than 1 cancer types. Because this analysis shows association rather than direction, both PML-to-partner and partner-to-PML results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FZD3 grouped by PML-low versus PML-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PML→partner) and Y-score (partner→PML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FZD3 →	+0.889	+2.628	<.001	.002	3	2
LARGE_INTESTINE	ARMC1 →	+0.481	+3.743	<.001	<.001	3	2
LARGE_INTESTINE	ARL6 →	+0.516	+2.628	<.001	.002	3	2
LARGE_INTESTINE	DPH5 →	+0.646	+2.628	<.001	.002	3	2
LARGE_INTESTINE	TTI2 →	+0.549	+2.628	.004	.002	3	2
LARGE_INTESTINE	ZIC5 →	+1.039	+3.321	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,184 associations by consensus.

FZD3 by PML expression — LARGE_INTESTINE

Explore this box plot interactively →