Across TCGA patient cohorts, PMEL mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PMEL-associated genes across cancer lineages are VHL, FoxM1, and ACC_pS79. Each is linked with PMEL in more than 1 cancer types. Because this analysis shows association rather than direction, both PMEL-to-partner and partner-to-PMEL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMEL→partner) and Y-score (partner→PMEL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.679	-2.000	.009	.029	3	2
UCEC	FoxM1 →	+0.203	+2.999	.041	.035	3	1
UCEC	ACC_pS79 →	+0.306	+2.179	.021	.034	3	1
UCEC	FOXO3a →	-0.097	-2.074	.012	.005	3	1
UCEC	ACC1 →	+0.353	+1.750	.011	.049	3	1
UCEC	p62 Lck ligand →	+0.350	+1.884	.005	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

PMEL survival (RNA) · tumor vs normal (RNA) · all PMEL data types