Across TCGA cell cohorts, PMEL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,633 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PMEL-associated GO terms across cancer lineages are Regulation of myoblast fusion, Negative regulation of syncytium formation by plasma membrane fusion, and Vacuolar transport. Each is linked with PMEL in more than 11 cancer types. Because this analysis shows association rather than direction, both PMEL-to-partner and partner-to-PMEL results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PMEL→partner) and Y-score (partner→PMEL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of myoblast fusion →	+0.127	+1.256	.001	.002	3	12
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.134	+1.203	.001	.003	3	11
OESOPHAGUS	Vacuolar transport →	+0.065	+1.425	<.001	<.001	3	11
URINARY_TRACT	Cilium movement involved in cell motility →	-0.080	-1.041	.001	<.001	3	11
OESOPHAGUS	Macroautophagy →	+0.079	+1.596	.001	.002	3	10
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.141	+1.256	.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,633 associations by consensus.

Exploration

PMEL survival (RNA) · tumor vs normal (RNA) · all PMEL data types