Across TCGA cell cohorts, PMEL mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PMEL-associated genes across cancer lineages are KLF14, BHLHE23, and OR10D3. Each is linked with PMEL in more than 1 cancer types. Because this analysis shows association rather than direction, both PMEL-to-partner and partner-to-PMEL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMEL→partner) and Y-score (partner→PMEL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KLF14 →	+0.071	+4.469	<.001	.001	3	2
LUNG_NSCLC_LUSC	BHLHE23 →	+0.020	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	OR10D3 →	+0.033	+4.643	<.001	.008	3	1
LARGE_INTESTINE	KRT71 →	+0.533	+3.520	.004	.005	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
BLOOD_Leukemia	MYOG →	+0.040	+3.769	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

PMEL survival (RNA) · tumor vs normal (RNA) · all PMEL data types