PMCHL1

Across TCGA patient cohorts, PMCHL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,696 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PMCHL1-associated GO terms across cancer lineages are mRNA 3'-end processing, Protein targeting to membrane, and Negative regulation of cell projection organization. Each is linked with PMCHL1 in more than 9 cancer types. Because this analysis shows association rather than direction, both PMCHL1-to-partner and partner-to-PMCHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA 3'-end processing grouped by PMCHL1-low versus PMCHL1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PMCHL1→partner) and Y-score (partner→PMCHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	mRNA 3'-end processing →	+0.063	+0.063	<.001	<.001	3	10
STAD	Protein targeting to membrane →	+0.056	+0.084	<.001	<.001	3	9
ESCA	Negative regulation of cell projection organization →	+0.053	+0.164	<.001	<.001	3	9
STAD	Regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.097	+0.135	<.001	<.001	3	9
STAD	Regulation of microtubule-based process →	+0.047	+0.077	<.001	<.001	3	9
STAD	Signal transduction by p53 class mediator →	+0.061	+0.086	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,696 associations by consensus.

mRNA 3'-end processing by PMCHL1 expression — STAD

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