PMCHL1

Across TCGA pan-cancer cohorts, PMCHL1 RNA is linked to patient survival in 7 of 34 cancer types, making it the most broadly survival-associated PMCHL1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PMCHL1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PMCHL1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and HNSC show a favorable association.

KIRP, ESCA, and LIHC are the cancer types where PMCHL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.197	0.711	.001	36	view →
ESCA	OS	Tertile	III,IV	0.663	0.368	.017	22	view →
LIHC	OS	Tertile	II,III,IV	0.327	0.708	.006	18	view →
HNSC	DFS	Tertile	II,III,IV	0.699	0.325	.028	12	view →
KIRC	DFS	Tertile	III,IV	0.306	0.498	.032	12	view →
STAD	DFS	Quartile	II,III,IV	0.440	0.572	.032	12	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	9	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PMCHL1–KIRP (OS)

Open the KIRP breakdown →