PM20D2

Across TCGA patient cohorts, PM20D2 mutation is significantly associated with the RNA expression of many other genes, with 83 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PM20D2-associated genes across cancer lineages are C2orf83, NPLP1, and RNU7-14P. Each is linked with PM20D2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PM20D2-to-partner and partner-to-PM20D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C2orf83 grouped by PM20D2-low versus PM20D2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PM20D2→partner) and Y-score (partner→PM20D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C2orf83 →	+0.127	+2.640	.002	.008	3	2
LUAD	NPLP1 →	+0.107	+3.754	<.001	.008	3	2
LUSC	RNU7-14P →	+0.576	+7.924	<.001	.008	3	2
UCEC	RN7SL726P →	+0.182	+3.488	.001	<.001	3	1
UCEC	MIR6129 →	+0.509	+2.496	<.001	.009	3	1
UCEC	LINC02340 →	+0.525	+3.245	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

C2orf83 by PM20D2 expression — UCEC

Explore this box plot interactively →