PM20D1

Across TCGA cell cohorts, PM20D1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PM20D1-associated genes across cancer lineages are CNR2, OOSP4A, and KRTAP10-10. Each is linked with PM20D1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PM20D1-to-partner and partner-to-PM20D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNR2 grouped by PM20D1-low versus PM20D1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PM20D1→partner) and Y-score (partner→PM20D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CNR2 →	+0.135	+4.070	<.001	<.001	3	2
CNS	OOSP4A →	+0.053	+5.321	<.001	.005	3	1
BREAST	KRTAP10-10 →	+0.036	+5.169	<.001	.005	3	1
OVARY	OR2M4 →	+0.070	+4.700	<.001	.002	3	1
OVARY	OR2AK2 →	+0.060	+4.029	<.001	.009	3	1
OVARY	OR2H1 →	+0.019	+4.029	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

CNR2 by PM20D1 expression — LARGE_INTESTINE

Explore this box plot interactively →