PLXND1

Across TCGA patient cohorts, PLXND1 protein abundance is significantly associated with the RNA expression of many other genes, with 18,085 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLXND1-associated genes across cancer lineages are C1orf54, IL6, and CD33. Each is linked with PLXND1 in more than 7 cancer types. Because this analysis shows association rather than direction, both PLXND1-to-partner and partner-to-PLXND1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLXND1 versus C1orf54 in HNSC, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXND1→partner) and Y-score (partner→PLXND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	C1orf54 →	+1.034	+0.258	<.001	<.001	3	8
GBM	IL6 →	+1.528	+0.312	<.001	<.001	3	8
OV	CD33 →	+0.661	+0.361	<.001	<.001	3	7
COAD	CSF3R →	+1.191	+0.325	<.001	.001	3	7
HNSC	SRGN →	+1.018	+0.193	<.001	<.001	3	7
GBM	SIGLEC9 →	+0.777	+0.275	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,085 associations by consensus.

PLXND1 vs C1orf54 — HNSC

Explore this scatter interactively →