PLXND1

Across TCGA patient cohorts, PLXND1 mutation is significantly associated with the total protein of many other genes, with 84 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PLXND1-associated genes across cancer lineages are PKC-b-II_pS660, eIF4E, and TIGAR. Each is linked with PLXND1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLXND1-to-partner and partner-to-PLXND1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by PLXND1-low versus PLXND1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXND1→partner) and Y-score (partner→PLXND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	PKC-b-II_pS660 →	-0.392	-3.000	.002	.034	3	4
COAD	eIF4E →	+0.183	+1.874	.001	.047	3	4
UCEC	TIGAR →	+0.137	+1.611	.002	.001	3	4
COAD	Rad50 →	-0.315	-2.807	<.001	.002	3	3
STAD	Rictor →	-1.134	-3.321	.006	.008	3	3
STAD	TFRC →	+0.646	+2.584	.013	.010	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

PKC-b-II_pS660 by PLXND1 expression — BLCA

Explore this box plot interactively →