PLXND1

Across TCGA cell cohorts, PLXND1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,095 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLXND1-associated GO terms across cancer lineages are Positive regulation of neurogenesis, Positive regulation of axonogenesis, and Protein targeting to lysosome. Each is linked with PLXND1 in more than 10 cancer types. Because this analysis shows association rather than direction, both PLXND1-to-partner and partner-to-PLXND1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of neurogenesis grouped by PLXND1-low versus PLXND1-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXND1→partner) and Y-score (partner→PLXND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Positive regulation of neurogenesis →	+0.052	+1.584	<.001	<.001	3	11
CNS	Positive regulation of axonogenesis →	+0.104	+1.927	<.001	<.001	3	10
BONE	Protein targeting to lysosome →	+0.084	+1.938	<.001	<.001	3	9
LARGE_INTESTINE	Negative regulation of smoothened signaling pathway →	+0.055	+1.843	<.001	.001	3	9
OVARY	Regulation of neurogenesis →	+0.051	+1.944	<.001	<.001	3	9
STOMACH	Nucleoside triphosphate metabolic process →	+0.064	+2.200	.002	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,095 associations by consensus.

Positive regulation of neurogenesis by PLXND1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →