PLXND1

Across TCGA cell cohorts, PLXND1 mutation is significantly associated with the RNA expression of many other genes, with 2,083 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLXND1-associated genes across cancer lineages are BCL11B, GPR182, and KSR2. Each is linked with PLXND1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLXND1-to-partner and partner-to-PLXND1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BCL11B grouped by PLXND1-low versus PLXND1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXND1→partner) and Y-score (partner→PLXND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BCL11B →	+2.757	+3.003	<.001	<.001	3	3
BLOOD_Leukemia	GPR182 →	+0.154	+2.503	<.001	.005	3	3
BLOOD_Leukemia	KSR2 →	+0.249	+2.830	<.001	<.001	3	3
CNS	HHLA1 →	+0.015	+3.643	.001	.006	3	3
UPPER_AERODIGESTIVE_TRACT	TRIM77 →	+0.022	+4.357	<.001	.006	3	2
LARGE_INTESTINE	SEPTIN3 →	+1.104	+2.129	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,083 associations by consensus.

BCL11B by PLXND1 expression — BLOOD_Leukemia

Explore this box plot interactively →