PLXNA2

Across TCGA patient cohorts, PLXNA2 mutation is significantly associated with the RNA expression of many other genes, with 4,896 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLXNA2-associated genes across cancer lineages are LARS2, WDHD1, and GNPNAT1. Each is linked with PLXNA2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLXNA2-to-partner and partner-to-PLXNA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LARS2 grouped by PLXNA2-low versus PLXNA2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXNA2→partner) and Y-score (partner→PLXNA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LARS2 →	+0.539	+3.189	.009	.008	3	4
UCEC	WDHD1 →	+0.444	+1.232	<.001	<.001	3	4
COAD	GNPNAT1 →	+0.498	+2.625	.005	.005	3	4
UCEC	VPS53 →	+0.271	+1.584	<.001	<.001	3	4
COAD	ATPAF2 →	+0.310	+2.761	.004	.002	3	4
COAD	LPAL2 →	-0.309	-3.480	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,896 associations by consensus.

LARS2 by PLXNA2 expression — CESC

Explore this box plot interactively →