PLXNA2

Across TCGA pan-cancer cohorts, PLXNA2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PLXNA2 data layer compared with 12 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PLXNA2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PLXNA2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

KIRC, ACC, and UCS are the cancer types where PLXNA2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.732	0.535	<.001	141	view →
ACC	DFS	Tertile	II,III,IV	0.279	0.698	<.001	72	view →
UCS	OS	Median	II,III,IV	0.709	0.308	.001	58	view →
KIRP	OS	Tertile	II,III,IV	0.230	0.837	.006	29	view →
LIHC	OS	Median	All	0.721	0.828	.004	22	view →
KICH	DFS	Median	II,III,IV	1.000	0.679	.022	14	view →
LUAD	DFS	Quartile	III,IV	0.680	0.389	.012	14	view →
SCLC	OS	Quartile	III,IV	0.795	0.401	.020	12	view →
LGG	OS	Tertile	All	0.739	0.868	.001	10	view →
UCEC	OS	Median	III,IV	0.694	0.475	.015	10	view →
READ	DFS	Quartile	All	0.655	0.876	.024	9	view →
HNSC	DFS	Tertile	IV	0.730	0.613	.029	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PLXNA2–KIRC (OS)

Open the KIRC breakdown →