PLXNA2

Across TCGA patient cohorts, PLXNA2 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLXNA2-associated genes across cancer lineages are p90 RSK, MSH2, and Smac. Each is linked with PLXNA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLXNA2-to-partner and partner-to-PLXNA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by PLXNA2-low versus PLXNA2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXNA2→partner) and Y-score (partner→PLXNA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	p90 RSK →	+0.230	+1.708	.022	.026	3	3
UCEC	MSH2 →	-0.306	-3.196	<.001	<.001	3	3
BLCA	Smac →	+0.260	+1.602	.011	.042	3	2
LUAD	FOXO3a →	-0.118	-3.000	.033	.035	3	2
SKCM	PAI-1 →	+0.741	+3.016	.006	.018	3	2
COAD	eIF4E →	+0.134	+2.334	.049	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

p90 RSK by PLXNA2 expression — COAD

Explore this box plot interactively →