PLXNA2

Across TCGA cell cohorts, PLXNA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,479 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PLXNA2-associated GO terms across cancer lineages are Regulation of gastrulation, Negative regulation of calcium ion transmembrane transporter activity, and Positive regulation of lamellipodium morphogenesis. Each is linked with PLXNA2 in more than 8 cancer types. Because this analysis shows association rather than direction, both PLXNA2-to-partner and partner-to-PLXNA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of gastrulation grouped by PLXNA2-low versus PLXNA2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXNA2→partner) and Y-score (partner→PLXNA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of gastrulation →	-0.245	-1.704	<.001	<.001	3	9
CNS	Negative regulation of calcium ion transmembrane transporter activity →	+0.106	+1.557	.001	<.001	3	8
STOMACH	Positive regulation of lamellipodium morphogenesis →	+0.217	+1.893	<.001	<.001	3	8
SOFT_TISSUE	Regulation of protein localization to cell leading edge →	-0.223	-2.067	<.001	<.001	3	8
URINARY_TRACT	Phospholipid translocation →	+0.084	+1.674	.001	<.001	3	8
BREAST	Cell-substrate junction organization →	+0.172	+1.839	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,479 associations by consensus.

Regulation of gastrulation by PLXNA2 expression — BONE

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