PLXNA2

Across TCGA cell cohorts, PLXNA2 mutation is significantly associated with the RNA expression of many other genes, with 1,826 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLXNA2-associated genes across cancer lineages are PAH, GAS8, and KSR2. Each is linked with PLXNA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLXNA2-to-partner and partner-to-PLXNA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAH grouped by PLXNA2-low versus PLXNA2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXNA2→partner) and Y-score (partner→PLXNA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PAH →	+0.611	+3.477	<.001	.009	3	3
LARGE_INTESTINE	GAS8 →	+0.609	+1.808	.001	.001	3	3
LARGE_INTESTINE	KSR2 →	+0.402	+1.458	<.001	.009	3	2
OESOPHAGUS	CCDC172 →	+0.024	+3.857	.003	.002	3	2
OESOPHAGUS	BPIFB3 →	+0.022	+3.857	<.001	.002	3	2
BLOOD_Lymphoma	OFCC1 →	+0.564	+3.877	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,826 associations by consensus.

PAH by PLXNA2 expression — BLOOD_Leukemia

Explore this box plot interactively →