PLXNA1

Across TCGA patient cohorts, PLXNA1 mutation is significantly associated with the RNA expression of many other genes, with 8,111 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLXNA1-associated genes across cancer lineages are NUDC, THAP3, and BNIP1. Each is linked with PLXNA1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PLXNA1-to-partner and partner-to-PLXNA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUDC grouped by PLXNA1-low versus PLXNA1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXNA1→partner) and Y-score (partner→PLXNA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NUDC →	+0.382	+2.657	<.001	<.001	3	5
CESC	THAP3 →	+0.317	+3.199	.007	.009	3	5
STAD	BNIP1 →	+0.387	+3.073	<.001	<.001	3	5
UCEC	RPA2 →	+0.294	+1.352	<.001	.001	3	5
STAD	RSL24D1 →	+0.354	+2.087	.002	.005	3	5
STAD	LRRN1 →	-1.011	-2.794	.004	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,111 associations by consensus.

NUDC by PLXNA1 expression — COAD

Explore this box plot interactively →